We leverage the natural properties of silk to treat osteoarthritis in the joint

Unique Material Properties

Silk has lubrication properties comparable to that of the body’s own synovial fluid. It is also has high tensile strength able to withstand the forces exerted on the joint.


Silk protein has been shown to be biocompatible and biodegradable in humans. We can inject formulations of silk into the joint space that are incorporated into the joint lining, the synovium.

Localized and Controlled Delivery

Silk protein can be formulated to release active small molecule or biologic drugs inside the joint over many months to provide long-term pain and inflammation relief.

Cocoon’s lead product: An osteoarthritis injection to provide extended pain relief

Dr. Ailis Tweed-Kent describes the genesis of Cocoon Biotech.